The 10 Best Anti-Aging Serums to Look for in Your 50s

Once collagen and elastin production is depleted, skin quickly loses elasticity and firmness, making wrinkles more visible and driving you to look for ways to plump up. Not to mention dark spots, inflammation, dryness and sensitivity. In fact, at maturity, skin needs it more than ever. That’s why we’ve introduced the best anti-aging serums for the 50s to help you address all the signs of aging, from wrinkles to loss of firmness, hyperpigmentation and dehydration, with powerful yet gentle formulas for skin that reacts easily.

What are the best anti-aging serums to use in your 50s?
When shopping for the best anti-aging serums for the 50s, we recommend looking for effective clinical-grade formulas that include restorative and renewing ingredients such as retinol, vitamin C and epidermal growth factor (EGF). In addition, they shouldn’t skip antioxidants to counteract photoaging and free radical damage, nor should they skip plumping ingredients that give skin elasticity, such as hyaluronic acid, squalane and lactic acid. Peels are not to be missed either – and by that I mean AHAs, one of the most effective anti-aging agents ever created to soften wrinkles and leave an even, reshaped tone. Ceramides, peptides and amino acids are also ideal additions to anti-aging serums of the 1950s because they lock in moisture and stop the transepidermal water loss that causes dryness .

You’re tempted to pick one up now, aren’t you?

Best Overall
Estee Lauder Advanced Night Repair Serum
This serum has what it takes to be the best overall anti-aging serum of the 50s because it does everything. It prevents UV-induced damage with Bifidobacterium ferment lysate, fortifies skin with peptides, yeast extracts and lactobacillus ferment, and hydrates with sodium hyaluronate and squalane. In addition, exclusive internal Chronolux™ Power Signal Technology supports cell renewal while increasing collagen production for firmer, more resilient skin.

Best used in conjunction with retinol
Murad Retinol Youth Renewal Serum
In addition to the fast-acting retinoids, this serum has added delayed-release retinol, which means it releases slowly into your skin to avoid irritation, plus a retinol booster for optimal results. According to the brand’s claims, Retinol Trio increases cell renewal, which softens wrinkles and reduces dark spots, revealing radiant, smooth skin in as little as three weeks. Bonus: The rich texture allows a little to go a long way, absorbing into the skin like a dream, leaving it nourished and plumped. Use it before applying moisturizer to your afternoon skincare routine to enjoy glowing and youthful skin in the morning.

Best with Vitamin C
Allies of Skin 35% Vitamin C+ Perfecting Serum
This serum is enriched with 35% vitamin C to dramatically brighten skin tone, boost collagen production and provide antioxidants for a refreshed look. We love it because its undiluted formula helps it stay clear and effective – that’s why we think it’s the best anti-aging serum for women over 50 because it contains vitamin C. In addition, the serum contains superoxide dismutase and glutathione, as well as two other potent ingredients antioxidants to enhance the effect of neutralizing free radicals.

Best for dehydrated skin
Glow Recipe Shea Butter Ceramide Repair Serum
One of the main causes of moisture loss is a weakened protective barrier. If not naturally occurring elements (such as ceramides), what else can strengthen the protective barrier? This serum is enriched with five of the same ceramides that lock in moisture as the skin, plus jojoba esters, avocado oil and peptides, all of which help prevent moisture loss and support barrier function. The gentle formula works like a charm on sensitive skin, working to reveal nourished, soothed and balanced skin.

Best if you have deep wrinkles
StriVectin Super-C Retinol Brightening and Correcting Vitamin C Serum
This serum is enriched with a high concentration of sodium ascorbyl phosphate (a stabilized form of vitamin C) retinol and sodium hyaluronate for triple anti-aging benefits that repair and brighten the complexion. striVectin Super-C Serum produces a firming effect thanks to the collagen-boosting power of retinol and vitamin C, while barrier-strengthening ferments, NIA-114™ and Antioxidant Blend counteracts photoaging. A godsend for dullness, rough texture, uneven tone, fine lines and loss of elasticity!

The best organic formula
Juice Beauty Stem Cell Anti-Wrinkle Retinol Serum
If your skin craves a clean, vegan formula, this is the one for you. Containing soy-derived retinol encased in evening primrose to promote skin renewal and emolliency, Juice Beauty Stem Cellular Anti-Wrinkle Serum has a creamy consistency that’s the perfect complement to your PM routine, so you wake up with firmer, plumper skin. What’s more, its blend of moisturizing and nourishing natural ingredients makes it one of the best organic serums to combat the signs of aging in the 1950s.

Best for Exfoliating
Drunk Elephant TLC Framboos Glycolic Acid Resurfacing Night Serum
Exfoliation is essential for softening wrinkles and removing dark spots, which is why we think this serum is perfect for women in their 50s. Not only does it contain 10% fruit acids, including glycolic, lactic and tartaric acids, but the formula is also infused with a variety of naturally derived elements to counteract the dryness associated with acid use. With diligent use, this serum can truly transform your skin, leaving it soft, even and smooth like a baby.

Best with EGF
SkinMedica TNS Advanced+ Serum
SkinMedica TNS Advanced+ Serum is more expensive, but worth every penny. The double-chambered bottle releases two powerful serums that accelerate the skin repair and renewal process and boost collagen levels. The formula’s MVP is TNS-MR, which contains 450 growth factors to help you fight the signs of aging in the shortest possible time. With a lightweight texture and no fragrance or alcohol, this serum is perfect for improving sagging skin and deep wrinkles to give you the best skin possible.

Best if you have the budget
The Ordinary Granactive Retioid 2% Squalane
It’s no secret that retinol is the gold standard ingredient in anti-aging. Well, this serum is infused with 2% granular active retinol on top of squalane in an effort to reduce the appearance of fine lines and wrinkles without causing irritation. We love the simplicity of this water-, fragrance-, alcohol- and paraben-free formula, and if you’re on a budget, it’s the perfect anti-aging serum for the 50s.

Best if you have sensitive skin
Tata Harper Skin Care Revitalizing Serum
During maturation, skin is usually very reactive. Therefore, you need a gentle formula that can suppress irritation while delivering. Ladies and gentlemen, a warm welcome to Tata Harper Skincare Rejuvenating Serum, the best anti-aging serum of the 50’s, in a gentle yet effective formula. This serum promises to reverse time with a blend of naturally derived elements that vow to reduce wrinkles, tighten, brighten and plump the skin. Notable ingredients are vitamins A and C, phytic acid, hyaluronic acid, sodium hyaluronate and safflower oil plasmid.